Oxidative DNA damage is one of the metabolic precursors to cancer and coronary vascular disease and phenols are organic compounds with antioxidant properties. A study conducted in Florence, Italy measured the oxidative DNA damage in ten healthy, post-menopausal women when they consumed olive oils with diﬀerent concentrations of natural phenols. Subjects replaced fats and oils habitually consumed with the study oil (50g/d), which was either a high-phenol extra virgin olive oil (592 mg total phenols/kg) or a low-phenol extra virgin olive oil (147 mg total phenols/kg) for eight weeks in each period. The study found that during treatment of high-phenol-EVOO, the average oxidative DNA damage was 30% lower than the average during low-phenol-EVOO treatment. Though the sample size was small, the study indicated that consuming an extra-virgin olive oil rich in phenols, particularly hydroxytryosol, may reduce DNA damage.
British Journal of Nutrition 2006 Apr; 95(4): 742-51 (Salvini et al.)