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Mediterranean Diet Linked with 44% Lower Risk of Heart Disease

Prospective studies, which follow groups of people over long periods of time, help researchers to identify patterns for chronic diseases like heart disease that often appear later in life. In this prospective study, nearly 2,000 adults were followed for 20 years to see if their diet had any relationship with developing heart disease down the road. Those most closely following a Mediterranean diet were 44% less likely to develop cardiovascular disease during the 20-year study, even after adjusting for family history, smoking, physical activity, and other risk factors. The authors also suggested that inflammation and kidney function may play a role in this relationship.
Nutr Metab Cardiovasc Dis. 2024 Jan;34(1):153-166. doi: 10.1016/j.numecd.2023.09.019. (Georgoulis M et al.)

Mediterranean Diet Linked with Lower Risk of Heart Disease, Death in At-Risk Individuals

At Mediterranean diet is well-known for its link with heart health, but researchers wanted to see how this tried-and-true eating pattern stacks up against other popular diet plans, like low carb or low sodium. In this systematic review and meta-analysis, researchers analyzed 40 studies in which a total of more than 35,000 people at risk of heart disease were randomly assigned to 7 different popular diets or a minimal intervention control group, to see which popular diets are most effective of preventing heart disease and mortality. They found that Mediterranean diets reduce the risk of all-cause mortality by 28%, heart disease mortality by 45%, stroke by 35%, and nonfatal heart attacks by 52%. Mediterranean diets were more effective than any other diet studied, many of which were no better than the control group.
BMJ. 2023 Mar 29;380:e072003. doi: 10.1136/bmj-2022-072003. (Karam G et al.)

Mediterranean Diet Linked with 25% Lower Risk of Coronary Heart Disease in Women

Heart disease is the number one cause of death in women, meaning that lifestyle changes to support heart health are of the utmost importance. In a meta-analysis of 16 prospective cohort studies (in which more than 700,000 women were followed over time), women most closely following a Mediterranean diet were 24% less likely to develop cardiovascular disease, were 23% less likely to die, and were 25% less likely to develop coronary heart disease than those not following a Mediterranean diet.
Heart. 2023 Mar 14;heartjnl-2022-321930. doi: 10.1136/heartjnl-2022-321930. (Pant A et al.)

Mediterranean Diet Reduces Risk of Heart Attack and Stroke

Randomized controlled trials, in which people are randomly assigned to a particular treatment and then monitored over time, are considered by many to be the “gold standard” of nutrition research. In this randomized controlled trial, 1,002 Spanish adults (average age 59) with heart disease were randomly assigned to a Mediterranean diet or a control diet (which differed by emphasizing lean meats and fish and low-fat dairy, and restricting fatty fish, nuts and olive oil) and followed for 7 years. Those eating a Mediterranean diet were 25-29% less likely to have a major cardiovascular event (such as a heart attack or stroke) than those eating the control diet, with the relationship being especially strong in men. These findings are consistent with previous research noting the cardioprotective benefits of a Mediterranean diet. 
Lancet. 2022 May 4;S0140-6736(22)00122-2. doi: 10.1016/S0140-6736(22)00122-2. (Delgado-Lista J et al.)

Mediterranean Diet Can Slow Progression of Atherosclerosis

Atherosclerosis, the build up of fatty plaque in arteries, can be a risk factor for heart disease down the road. In a randomized controlled trial of more than 900 people with heart disease, those assigned to a Mediterranean diet improved their atherosclerosis (as measured by reduced thickness of both carotid arteries) over 5 years and maintained their baseline artery thickness at 7 years. Those assigned to a low-fat diet did not have any significant improvements in atherosclerosis.
Stroke. 2021 Aug 10;STROKEAHA120033214. doi: 10.1161/STROKEAHA.120.033214. (Jimenez-Torres J et al.)

Mediterranean Diet Linked with Better Blood Vessel Function in Adults with Heart Disease

The endothelium lines the heart and blood vessels, and when not working properly, can be an indicator of atherosclerosis (dangerous buildup of fatty plaques in arteries). In this study, researchers randomly assigned 805 adults with coronary heart disease to a Mediterranean diet or a low-fat control diet and measured their endothelial function. After 1 year on their respective diets, those following a Mediterranean diet were more likely to have improved endothelial function and better homeostasis of their blood vessels, even in patients with severe endothelial dysfunction.
PLoS Medicine. 2020 Sep 9;17(9):e1003282. doi: 10.1371/journal.pmed.1003282. eCollection 2020 Sep. (Yubero-Serrano EM et al.)

Olive Oil Linked with Lower Risk of Heart Disease

Not all fats are created equal. Olive oil is a source of heart-healthy monounsaturated fats and polyphenols, while butter is a source of saturated fats. In this study, researchers followed more than 90,000 people for 24 years. Those eating more than ½ tablespoon of olive oil per day had a 14-17% lower risk of heart disease compared with people who didn’t eat olive oil. The scientists also found that replacing 5g/day of butter, margarine, mayonnaise, or dairy fat with the equivalent amount of olive oil was also linked with a 5-7% lower risk of heart disease.
J Am Coll Cardiol. 2020 Apr 21;75(15):1729-1739. doi: 10.1016/j.jacc.2020.02.036. Epub 2020 Mar 5. (Guasch-Ferré M et al.)

Mediterranean Diet Linked with Better Brain Function in Men with Heart Disease

The Mediterranean diet is well-known for its links to brain health, and new research demonstrates that these ties hold up in populations with heart disease as well. In this study, researchers analyzed the diets of 200 men (average age 57), then assessed their brain health 14 and 20 years later. Not following a Mediterranean Diet was linked with a greater decline in overall cognitive performance and visual spatial functions.
Nutritional Neuroscience. 2020 Jan 22:1-9. doi: 10.1080/1028415X.2020.1715049. (Lutski M et al.)

Chili Pepper Linked with Longevity in Italian Adults

Chili pepper is an underappreciated aspect of a Mediterranean diet. To see how it relates to longevity in a Mediterranean population, researchers analyzed the diets of 22,811 Italian adults and monitored their health outcomes for 8 years. Those eating chili pepper at least 4 times per week were 23% less likely to die from all causes and 34% less likely to die from heart disease over the study period, even after controlling for the benefits of a Mediterranean diet. The relationship seems to be strongest in people without high blood pressure.
Journal of the American College of Cardiology. 2019 Dec 24;74(25):3139-3149. doi: 10.1016/j.jacc.2019.09.068. (Bonaccio M et al.)

Mediterranean Diet Linked with Improvements in Cardiodiabesity

“Cardiodiabesity” is an umbrella term which refers to the relationship between obesity, cardiovascular disease, metabolic syndrome, and type 2 diabetes. Researchers analyzed over 50 studies to answer several key questions about the impact of the Mediterranean diet on cardiodiabesity. The researchers found strong evidence that following the Mediterranean diet reduces obesity, blood pressure, and the risk of cardiovascular disease in healthy and at-risk people. They also found moderate evidence that the Mediterranean diet reduces the risk of developing metabolic syndrome and type 2 diabetes, and can reduce the symptoms of type 2 diabetes in diabetics.
Nutrients. 2019 Mar 18;11(3). pii: E655. doi: 10.3390/nu11030655. (Franquesa M. et al)

Mediterranean Diet Has Long History of Health Benefits

Mediterranean diet first rose to prominence in the 1950’s and since that time has become one of the most-studied diets in the world. In this study, researchers summarize the Mediterranean diet’s scientific history and key takeaways, including its benefits for weight loss and the prevention of heart disease and type II diabetes. The Mediterranean diet has also been linked with the possible prevention of certain types of cancer and neurodegenerative diseases such as Alzheimer’s. The authors note that the erosion of tradition threatens the Mediterranean diet in its place of birth, and that more populations could benefit from adopting a more Mediterranean inspired diet.
International Journal of Environmental Research and Public Health. 2019 Mar 15;16(6). pii:E942. doi: 10.3390/ijerph16060942. (Lăcătușu C-M et al.)

Mediterranean Diet May Help Prevent Heart Disease

Cochrane reviews are some of the most rigorous reviews in scientific research. In this Cochrane review, researchers analyzed 30 existing randomized controlled trials (the “gold standard” of nutrition research) and 7 ongoing trials of the Mediterranean diet and its impact on heart disease risk. The study found small to moderate evidence for benefits of the Mediterranean diet for preventing heart disease, but note that more research is needed to better understand the benefits, particularly in patients who already have heart disease.
The Cochrane Database of Systematic Reviews. 2019 Mar 13;3:CD009825. doi: 10.1002/14651858.CD009825.pub3. (Rees K et al.)

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