Age related macular degeneration (AMD) is the leading cause of vision loss in older adults, mostly occurring in those over 60 years old. To see if eating patterns play a role in this disease, researchers analyzed the diet of nearly 900 Portuguese adults (ages 55+), half with AMD, and half without. Those without AMD ate foods more closely aligned with the Mediterranean diet (grains, green leafy vegetables, fruit, and olive oil) than those who did have AMD. The group without AMD also exercised more, and ate less fast food, meat, dairy, and ready-made meals. This study suggests that a Mediterranean style diet, along with exercise, may be protective against AMD.
Presentation at the European Society of Retina Specialists 15th EURETINA Congress. Nice, France. September 17, 2015. (Farina C et al.)

With incidence of breast cancer increasing in recent years, lifestyle and prevention measures are more important than ever. Using data from the PREDIMED study (where adults at risk for heart disease were assigned to either a low fat diet, a Mediterranean diet with olive oil, or a Mediterranean diet with nuts), scientists analyzed the eating patterns and health outcomes of over 4,200 women (ages 60-80). During the 5-year follow up period, 35 women developed breast cancer.  Those in the Mediterranean diet groups were 51% less likely to get breast cancer than those on a low-fat diet. The Mediterranean diet with olive oil group was 62% less likely to get breast cancer, while the Mediterranean diet group with nuts had a non-significant lower risk of breast cancer.
JAMA Internal Medicine. 2015 Sep 14:1-9. [Epub ahead of print.] (Toledo E et al.)

Complications from diabetes can lead to serious health problems, including vision impairment, blindness, and kidney damage. Using data from the PREDIMED study (where adults at risk for heart disease were assigned to either a low fat diet, a Mediterranean diet with olive oil, or a Mediterranean diet with nuts), researchers analyzed data from over 3,600 Spanish adults with type 2 diabetes, to see how diet affects the risk of diabetic nephropathy (kidney damage from diabetes) or diabetic retinopathy (eye damage from diabetes). Those following a Mediterranean diet with olive oil had a 43% lower risk of diabetic retinopathy compared to the low fat control group, and those following a Mediterranean diet with nuts had a non-significant 38% lower risk of diabetic retinopathy. There were no significant changes in the risk for diabetic nephropathy.
Diabetes Care. 2015 Sept 13. [Epub ahead of print] (Diaz-Lopez A et al.)

Fish is well known for its place in many of the healthiest diets around the world. To determine the link between eating fish and depression risk, Chinese scientists reviewed 26 studies of over 150,000 people. The researchers concluded that “high fish consumption can reduce the risk of depression.”  
Journal of Epidemiology and Community Health. 2015 Sep 10. pii: jech-2015-206278. [Epub ahead of print.] (Li Fu et al.)

Congenital heart defects (heart problems that occur before birth) affect nearly 1% of newborns in America. In a study of over 19,000 American women, researchers compared mothers of babies with congenital heart defects to mothers of babies without this condition. Scientists analyzed the mothers’ diets in the year before pregnancy using both the Mediterranean Diet Score and the Diet Quality Index for Pregnancy. Babies whose moms’ diets ranked healthy on both scores were significantly less likely to suffer from certain specific subgroups of congenital heart defects, such as tetralogy of Fallot (a defect in heart structure which causes oxygen poor blood to flow throughout the body), but not all heart defects. The relationship between diet and congenital heart defects was stronger with the Diet Quality Index for Pregnancy than with the Mediterranean Diet.
Archives of Disease in Childhood. Fetal and Neonatal Edition. 2015 August 24. pii: fetalneonatal-2014-308013. [Epub ahead of print.] (Botto LD et al.) 

Palmitic acid (found in palm oil, shortening, butter, and red meat) is a type of saturated fat prevalent in the Western diet, while oleic acid (found in olive oil) is a type of monounsaturated fat prevalent in the Mediterranean diet. In a small study, researchers at the University of Vermont fed 16 adults either a diet high in palmitic acid or a diet high in oleic acid and low in palmitic acid to see how food choices affect the inflammatory response of various cells. All adults spent 3 weeks in each diet group, serving as their own control.  Although insulin sensitivity was not affected in this experiment, the scientists found that changing the diet to include more oleic acid and less palmitic acid was able to lower activation of certain cell signaling proteins (including TLR4 and NLRP3) that are associated with inflammation, oxidation and poor insulin signaling. These results suggest that shifting from a Western diet to a Mediterranean style diet (with greater proportions of oleic acid) may help fight inflammation.
Journal of Nutritional Biochemistry. 2015 Aug 1. pii: S0955-2863(15)00178-3. (Kien CL et al.)

In a small Italian study, researchers assigned 25 healthy adults to a Mediterranean meal (pasta, chicken breast, salad, bread, and an apple) prepared either with or without olive oil, then measured their cholesterol and blood sugar. After 30 days, the participants switched groups and ate the other meal, serving as their own control. The scientists found that 2 hours after eating, the meal without olive oil was associated with higher glucose and insulin levels, as well as higher “bad cholesterol” (LDL-C). In the second part of the experiment, the participants were assigned to a Mediterranean meal prepared with either olive oil or corn oil, switching groups after a 30 day washout period. Their blood sugar and cholesterol was tested after the meals as well. Two hours after eating, the meals with olive oil were associated with a lower increase in blood sugar and improved markers of blood sugar control (such as lower DPP, and higher GLP1 & GIP), as well as a smaller increase in “bad cholesterol” (LDL-C and oxidized LDL). These experiments indicate that meals with olive oil can help regulate blood sugar, and may help improve cholesterol.
Nutrition & Diabetes. 2015 July 20;5:e172. [Epub ahead of print.] (Violi F et al.)

Endometrial cancer, also known as womb cancer, is largely determined by hormone levels in the body. However, new research shows that diet can play an important role in prevention. Combining the results of three large studies, Italian researchers analyzed the eating patterns of over 5,000 women in Europe (1411 with endometrial cancer, and 3668 controls) for their adherence to the Mediterranean diet. Those most closely following the Mediterranean diet were over 50% less likely to develop endometrial cancer than those with the lowest adherence to the Mediterranean diet. Additionally, researchers found that “the Mediterranean diet as a whole is a stronger determinant of endometrial cancer risk than the single dietary components,” emphasizing the importance of overall diet.
British Journal of Cancer. 2015 May 26;112(11):1816-21. (Filomeno et al.) 

Nuts have long been associated with longevity, and new research in diverse populations further supports this relationship. Researchers tracked peanut and nut intake of about 206,000 people in the US (low income blacks and whites) and China for over 5 years. High nut intake was associated with a 21% lower risk of death from all causes among the US participants, and a 17% lower risk in the Chinese participants. High nut and peanut intake was also associated with a lower risk of death from heart disease, especially in ischemic heart disease (the type of heart disease caused by narrowed arteries).
JAMA Internal Medicine. 2015 May;175(5):755-66. (Luu HN, et al.)

The Mediterranean diet has long been studied for its role in heart health and aging, but emerging research suggests that it may also be protective for brain health. In a follow up to the PREDIMED study (where Spanish adults at risk for heart disease were randomly assigned to either a Mediterranean diet with four tablespoons of olive oil daily, a Mediterranean diet with one ounce of nuts daily, or a low fat controlled diet) researchers analyzed the relationship between diet and cognitive function. Of the 334 participants in this study with data on cognitive function, the scientists found that overall brain function significantly improved for both Mediterranean groups over the 4-year experiment, compared with the control group. Specifically, the nuts group significantly improved on tests of memory, while the olive oil group significantly improved on tests of reasoning, planning, and problem solving. This adds to the growing body of research that the Mediterranean diet is an important factor in healthy aging.
JAMA Internal Medicine. 2015 May 11. [Epub ahead of print] (Valls-Pedret C et al.) 

Sardinia, Italy has gained international recognition as one of the world’s longevity Blue Zones, as it has a large concentration of people who live exceptionally long lives. To determine how the traditional Sardinian diet might play a role in longevity, European researchers analyzed the traditional eating habits of Sardinia based on works published over a century. Researchers characterize the traditional Sardinian diet as “remarkably frugal.” Foods native to the Sardinian diet include grains (wheat and barley), potatoes, pulses, sheep milk and goat milk and their fresh cheeses, wild fruits, and fresh vegetables, with fermented whole grain breads and minestrone soup making up a substantial portion of the diet prior to the 1950’s. After the mid-1950’s, Sardinians were able to eat more meat and pasta, along with more fresh vegetables, olive oil, and fish, but with fewer potatoes, pulses, and less lard. The researchers conclude that this unique combination of diets may attribute to the exceptionally long lifespan of Sardinians born at the end of the 19th century, and are eager to monitor the lifespan of future generations of Sardinians.
European Journal of Clinical Nutrition. 2015 Apr;69(4):411-8. (Pes GM et al.)