Heart disease is the number one cause of death in women, meaning that lifestyle changes to support heart health are of the utmost importance. In a meta-analysis of 16 prospective cohort studies (in which more than 700,000 women were followed over time), women most closely following a Mediterranean diet were 24% less likely to develop cardiovascular disease, were 23% less likely to die, and were 25% less likely to develop coronary heart disease than those not following a Mediterranean diet.
Heart. 2023 Mar 14;heartjnl-2022-321930. doi: 10.1136/heartjnl-2022-321930. (Pant A et al.)

Mediterranean diets have been linked with brain health and lower dementia risk in small studies, but researchers wanted to see how this relationship holds up in larger studies and in people who are genetically predisposed to dementia. In a study of 60,298 older adults in the UK, those most closely following a Mediterranean diet were 23% less likely to develop dementia over the 9 year study period, independent of a person’s genetic risk for dementia.
BMC Med. 2023 Mar 14;21(1):81. doi: 10.1186/s12916-023-02772-3. (Shannon OM et al.)

Adverse pregnancy outcomes (such as preeclampsia, eclampsia, gestational hypertension, gestational diabetes, preterm birth, small-for-gestational age, and stillbirth) can put both mothers and babies at risk. In this prospective study of 7,798 pregnant women across the US, those most closely following a Mediterranean diet were 21% less likely to develop any of the adverse pregnancy outcomes described above and were also 28% less likely to develop preeclampsia and 37% less likely to develop gestational diabetes. The researchers noted a dose-response relationship for risk of adverse pregnancy outcomes, meaning that the closer a mother’s diet aligned with the Mediterranean diet, the lower the risk.
JAMA Netw Open. 2022 Dec 1;5(12):e2248165. doi: 10.1001/jamanetworkopen.2022.48165.

Frailty in aging may lead to falls, fractures, disability, and other serious health risks, so dietary strategies to prevent frailty in older adults are of great importance. In a study of 2,384 nonfrail adults from the Framingham Offspring Study (average age 60 years), those most closely following a Mediterranean diet had a 38% lower risk of developing frailty than those not adhering to a Mediterranean diet. Additionally, each 10-mg increase of total carotenoids and vitamin E (antioxidants found in many Mediterranean diet foods) reduced the risk of frailty by 16%.
Am J Clin Nutr. 2022 Sep 2;116(3):630-639. doi: 10.1093/ajcn/nqac130. (Millar et al.)

Healthy life expectancy is a measure of how long a person lives in “full health” without disease or injury. In an analysis of the diets and health outcomes of people in 130 countries around the world, following a Mediterranean diet was significantly associated with both life expectancy and healthy life expectancy even after controlling for things like socio-economic status and health indicators.
J Nutr Health Aging. 2022;26(6):621-627. doi: 10.1007/s12603-022-1811-y. (A Sezaki et al.)

Randomized controlled trials, in which people are randomly assigned to a particular treatment and then monitored over time, are considered by many to be the “gold standard” of nutrition research. In this randomized controlled trial, 1,002 Spanish adults (average age 59) with heart disease were randomly assigned to a Mediterranean diet or a control diet (which differed by emphasizing lean meats and fish and low-fat dairy, and restricting fatty fish, nuts and olive oil) and followed for 7 years. Those eating a Mediterranean diet were 25-29% less likely to have a major cardiovascular event (such as a heart attack or stroke) than those eating the control diet, with the relationship being especially strong in men. These findings are consistent with previous research noting the cardioprotective benefits of a Mediterranean diet. 
Lancet. 2022 May 4;S0140-6736(22)00122-2. doi: 10.1016/S0140-6736(22)00122-2. (Delgado-Lista J et al.)

Preeclampsia is a pregnancy complication characterized by a rapid rise in blood pressure. In this study, researchers surveyed a diverse cohort of Black, Hispanic, and white low-income mothers in Boston about their diet and searched their health records for diagnoses of preeclampsia. Greater adherence to the Mediterranean diet was linked with a 22% lower risk of preeclampsia overall, with significant risk reduction for each of the racial groups.
Journal of the American Heart Association. 2022 May 3;11(9):e022589. doi: 10.1161/JAHA.121.022589. (Minhas AS et al.)

Diet and lifestyle are thought to play a role in the risk for neurodegenerative diseases like Alzheimer’s and Parkinson’s, and researchers wonder if the gut microbiome may modulate this relationship. A review of 64 studies analyzed the relationship between the Mediterranean diet and risk of Alzheimer’s disease and/or Parkinson’s disease, as well as the relationship between the makeup of the gut microbiome and its association with both diet and neurodegenerative diseases. Greater adherence to a Mediterranean diet was linked with a lower risk of both Alzheimer’s and Parkinson’s disease. The study also identified specific genera and species of bacteria that had an inverse relationship with the Mediterranean diet and these diseases, suggesting that the gut microbiota may play a role in this relationship.
J Neurol Sci. 2022 Mar 15:434:120166. doi: 10.1016/j.jns.2022.120166. (Solch RJ et al.)

The Mediterranean diet is thought to be neurologically protective, so researchers wanted to learn more about the diet’s relationship with neurodegenerative diseases like Alzheimer’s and Parkinson’s. In this study, researchers analyzed 64 articles about the Mediterranean diet, microbiome health, and Alzheimer’s disease or Parkinson’s disease. They found that following a Mediterranean diet is linked with a lower risk of Alzheimer’s Disease and Parkinson’s Disease (with the link for Alzheimer’s being particularly strong). However, it is unclear if the Mediterranean diet promotes gut microbiome health and brain health via two separate mechanisms or if one factor causes another.
Journal of the Neurological Sciences. 2022 Mar 15;434:120166. doi: 10.1016/j.jns.2022.120166. (Solch RJ et al.)

Healthy eating may reduce the risk of age-related diseases and potentially even increase longevity, so researchers wanted to learn more about the mechanisms behind this protective effect. In this review, researchers share how the Mediterranean diet impacts nine different cellular and molecular hallmarks of aging (including telomere attrition, altered intercellular communication, and deregulated nutrient sensing, among others), thus supporting healthy aging.
European Journal of Clinical Nutrition. 2021 Aug;75(8):1176-1192. doi: 10.1038/s41430-020-00841-x. (Shannon OM et al.)

Atherosclerosis, the build up of fatty plaque in arteries, can be a risk factor for heart disease down the road. In a randomized controlled trial of more than 900 people with heart disease, those assigned to a Mediterranean diet improved their atherosclerosis (as measured by reduced thickness of both carotid arteries) over 5 years and maintained their baseline artery thickness at 7 years. Those assigned to a low-fat diet did not have any significant improvements in atherosclerosis.
Stroke. 2021 Aug 10;STROKEAHA120033214. doi: 10.1161/STROKEAHA.120.033214. (Jimenez-Torres J et al.)

Can healthy eating habits rub off on family members who aren’t actively trying to eat better? New research seems to suggest so. In this study, scientists analyzed the diet, weight, and exercise habits of 148 untreated family members of people participating in the PREDIMED-Plus study, a Mediterranean diet weight loss intervention. After two years, the untreated family members lost nearly 9 pounds and scored significantly better on the Mediterranean diet score, indicating a “halo effect” of their family members’ participation in the study. There were no significant changes to the exercise habits of the untreated family members.
International Journal of Obesity. 2021 Jun;45(6):1240-1248. doi: 10.1038/s41366-021-00763-z. Epub 2021 Mar 3. (Zomeño MD et al.)