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Cardioprotective Effect of Mediterranean Diet

Ventricular hypertrophy, or the thickening and enlargement of heart ventricles due to the accumulation of scar tissue, is thought to be a root cause of many heart ailments. To investigate how diet relates to this condition, researchers analyzed eating patterns and left ventricular mass (the size of the left ventricle of the heart, where enlargement is most common) of over 1,700 adults without history of heart attack or stroke. The scientists found that those most closely adhering to a Mediterranean Diet had a left ventricular mass that was 4% less than the rest of the study population, a reduction greater than that observed in people with moderate-to-heavy physical activity (another factor that supports heart health). In fact, for each point increase on the Mediterranean Diet Score (0-9), left ventricular mass was 1.98g lower (average left ventricular mass was 189g).
American Journal of Cardiology. 2015 Feb 15;115(4):510-4. (Gardener H et al.)

Mediterranean Diet Linked with Better Heart Health

The Mediterranean diet is not as pervasive in Mediterranean nations as it once was, but research indicates that adopting this traditional pattern of eating could have widespread benefits. Researchers in Turkey analyzed the eating habits of 900 adults without heart disease, then monitored their health for 5 years. Men and women most closely following a Mediterranean diet were significantly less likely to have a heart attack or need a stent to open up their blood vessels. Additionally, the men most closely following a Mediterranean diet had significantly lower rates of coronary artery disease (the most common type of heart disease) and coronary bypass grafts (surgery to improve blood flow to the heart). However, in women, the lower rates of coronary artery disease and coronary bypass grafts were not statistically significant.
International Journal of Clinical and Experimental Medicine. 2015 Feb 15;8(2):2860-6. (Hoscan Y et al.)

Olive Oil May Decrease Risk for Coronary Artery Disease

The Mediterranean Diet has long been associated with a reduced risk of heart disease, so researchers decided to take a closer look at how olive oil, one of the staples of this cuisine, might play a role in heart health. In a European study, researchers gave 63 healthy participants a daily 20 ml supplement of either refined olive oil (low phenolic content) or extra virgin olive oil (high phenolic content) for six weeks. Then researchers measured the participants for urinary proteomic biomarkers (certain peptides in the urine that are associated with specific diseases). After the six-week supplementation, both olive oil groups showed a significant improvement in the biomarkers for coronary artery disease, but no significant difference in the biomarkers for diabetes or chronic kidney disease, and no significant change in cholesterol levels.
American Journal of Clinical Nutrition. 2014 Nov 19 [Epub ahead of print] (Silva S et al.)

Mediterranean Diet May Protect Against Inflammatory Diseases

Chronic inflammation (the body’s response to stress) is linked with a number of diseases. To see how diet may play a role, Spanish researchers reviewed data on the Mediterranean diet and inflammatory disease, and found that following a Mediterranean diet is linked with both short and long term benefits for inflammatory diseases. In the short term, Mediterranean diets can help reduce risk factors associated with cardiovascular disease, like blood pressure and cholesterol. But the benefits of following a Med diet persist over time. In the long term, following this eating pattern has an intense, systemic, anti−inflammatory effect. This suggests that adherence to a Mediterranean diet may help protect against diseases like atherosclerosis, cancer, and neurodegenerative diseases, such as Alzheimers disease.
Endocrine, Metabolic & Immune Disorders−Drug Targets. 2014 Nov;14:245−254. (Casas R et al.)

Mediterranean Diet Can Reverse Metabolic Syndrome

Metabolic syndrome is a dangerous cluster of 3 or more conditions: central obesity (storing fat around your middle), high blood pressure, high triglycerides (a type of fat in your blood), high LDL (bad) cholesterol, low HDL (good) cholesterol, and high blood sugar. Metabolic syndrome greatly increases your risk for heart disease and diabetes, but luckily, researchers found a delicious way to reverse the condition. Scientists in Spain reviewed data collected during the PREDIMED study in which over 7,400 adults at risk of heart disease were randomly assigned to eat 1 of 3 diets: Mediterranean Diet supplemented with extra-virgin olive oil, Mediterranean Diet supplemented with nuts, or a control diet (patients received advice on a low-fat diet). Researchers found that while the Mediterranean diet was not associated with the onset of metabolic syndrome, reversal of the condition (decrease in central obesity and/or high blood sugar) occurred in nearly one third of patients eating either version of the delicious and nutritious Mediterranean diet.
Canadian Medical Association Journal. 2014 Oct 14. Pii:cmaj.140764. [Epub ahead of print] (Babio N et al).

Fat in Olive Oil Can Help Revive Ailing Hearts

We’ve long known that a Mediterranean inspired diet rich in olive oil is associated with disease prevention, but recent studies are showing promise in disease treatment as well. In an animal study at the University of Illinois, either palmitate (the dietary fat found in animal fats, dairy, and palm oil) or oleate (the dietary fat found in olive oil) was delivered directly to beating rat hearts with heart failure. The palmitate treated hearts continued failing, with depressed fat metabolism and storage. On the other hand, the oleate treated hearts greatly improved, with restored fat content in cells, improved contraction, and normalized fat metabolism genes. In fact, after observing the hearts treated with oleate, the scientists declared that the fat content, turnover, and oxidation in the failing hearts “were indistinguishable from those of the healthy heart.”
Circulation. 2014 September 29, pii [Epub ahead of print] (Lahey R et al.)

Mediterranean Diet Decreases Diabetes Risk

Researchers in Vienna, Austria reviewed data from over 122,000 adults to investigate the association between the Mediterranean diet and diabetes risk. After analyzing eight prospective cohort studies and one clinical controlled trial published between 2007 and 2014, the scientists found that greater adherence to a Mediterranean diet is associated with a significant reduction (19%) in the risk of type 2 diabetes.
Public Health Nutrition. 2014 Aug 22 [Epub ahead of print] (Schwingshackl L et al.)

Long term improvement in vascular function after Mediterranean diet

A healthy vascular system is crucial to delivering oxygen and nutrients to body tissues, and research is showing that even short-term dietary changes can provide long-term benefits. In a small study in the United Kingdom, 22 healthy older individuals (average age = 55 years) followed an 8-week exercise program, and half of the individuals were randomly assigned to a Mediterranean diet for that time period. One year later, 20 of the individuals returned for a follow-up assessment testing their vascular function. The vascular function for both groups had improved from before the original 8-week trial, but the Mediterranean diet group showed an even greater improvement than the exercise-only group.
Microvascular Research. 2014 Aug 7;95C:103-107 (Klonizakis M et al.)

Med Diet Slows Diabetes Progression

The Mediterranean Diet slowed the progression of type 2 diabetes more than a low-fat diet, in a recent randomized controlled trial in Naples, Italy, of 215 adults recently diagnosed with diabetes. The Med Diet group ate a diet high in olive oil, vegetables and whole grains, with poultry and fish replacing most red meat, while the low-fat group concentrated on restricting fatty or sugary snacks and limiting overall fat. At the six-year mark, all the people in the low-fat group needed medication, while some in the Med group were able to delay medication for two more years. People on the Med Diet also tended to lose more weight and to stick with the diet even after the trial ended.
Diabetes Care, ePub April 10, 2014. Esposito et al.
 

Med Diet May Help Cut Diabetes Risk without Cutting Calories

Researchers reviewed data collected during the PREDIMED study in which more than 3500 patients aged 55 to 80 years with high cardiovascular risk were randomly assigned to eat 1 of 3 diets: Mediterranean Diet supplemented with extra-virgin olive oil, Mediterranean Diet supplemented with nuts, or a control diet (patients received advice on a low-fat diet). None of the diets were calorie restricted. Over the course of the study 16% of the participants on a Med Diet enriched with extra-virgin olive oil and 18.7% of those on the Med Diet plus nuts developed type 2 diabetes, compared to 23.6% of the participants on the control diet, leading researchers to conclude that a Mediterranean Diet enriched with olive oil but without calorie restrictions can reduce diabetes risk for people with high cardiovascular risk.

Annals of Internal Medicine. 2014; 160(1):10-10-10. [Salas-Salvadó, et al].

Med Diet May Help Prevent Gestational Diabetes

Researchers assessed the dietary habits of more than 1000 pregnant women in 10 Mediterranean countries to determine their adherence to a Mediterranean Diet. The women were screened for gestational diabetes between their 24th and 32nd weeks of pregnancy. The researchers found that adherence to a Mediterranean Diet is associated with lower incidence of gestational diabetes. They call for further testing of the use of the Mediterranean Diet for the prevention of gestational diabetes.

European Journal of Clinical Nutrition. 2014; 68:8-13. [Karamanos, et al].

Soffrito Contains Healthy Antioxidants

Different Mediterranean soffritos (sautéed vegetables and spices, usually a combination of tomatoes, garlic, and onions cooked in olive oil) were analyzed for their content of healthy antioxidants. Researchers identified 40 different types of polyphenols, including some never previously reported in Mediterranean soffrito. Polyphenols are associated with low incidence of cardiovascular disease. The soffritos also contained other beneficial compounds such as carotenoids and vitamin C. The amount of the antioxidants differed among soffritos according to the type of vegetables or olive oil used to make them. Researchers also discovered that the health benefits obtained from soffrito are better than the benefits obtained from eating each ingredient separately.

Food Chemistry. 2013 Dec 15; 141(4): 3365-3372 (Vallverdú-Querald, et al.) [EPub ahead of print]

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