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A Little Wine May Be Protective, Post Heart Attack

While many studies have shown that moderate consumption of wine may help prevent cardiovascular disease, scientists in Dijon, France set out to see if moderate wine intake after myocardial infarction would be beneficial. Their two-week clinical intervention trial divided patients into two groups: one following a Med-inspired diet with water, and the other following the same diet with 250ml of red wine. Those drinking the red wine showed a decrease in total cholesterol and LDL (“bad”) cholesterol as well as an increase in antioxidant status and in fluidity of red blood cell membranes.
Molecular Nutrition and Food Research. 2012 February; 56(2):345-51. [Rifler et al.]

Whole Grains: Key Component of Med Diet

University of Granada (Spain) researchers evaluated studies that support the consumption of whole grain cereals and bread, key components of the Mediterranean diet, to prevent chronic diseases.  Several studies have consistently shown that subjects who ingest three or more portions of whole-grain cereal-based foods per day have a 20-30% lower risk of coronary vascular disease than subjects who ingest low quantities of cereals.  This level of protection is not observed with ingestion of refined cereals.  Similarly, high intake of whole grain cereals and their products, such as whole-wheat bread, is associated with a 20-30% reduction in the risk of type-2 diabetes.  Finally, regular consumption of whole grain cereals and derived products has shown protection against the risk of colorectal cancer and polyps, other cancers of the digestive tract, cancers related to hormones, and pancreatic cancer, as well.
Journal of Public Health Nutrition 2011 Dec; 1412A):2316-22 (Gil et al.)

Med Diet Lowers Risk of Overall Heart Disease

Researchers at the University of Miami examined the relationship between a Mediterranean diet and risk of ischemic stroke, myocardial infarction, and vascular death among 2568 participants (black, Hispanic and white). Adherence to the Mediterranean diet was assessed using a food frequency questionnaire; the higher the score the greater the adherence to the Mediterranean diet.  The relationship between the Mediterranean diet and risk of ischemic stroke, myocardial infarction, and vascular death was assessed using Cox models, with control for socio-demographic and vascular risk factors.  Over a mean follow-up of 9 years, 518 vascular events accrued (171 ischemic strokes, 133 MI’s, and 314 vascular deaths).  The results of this study showed an inverse relationship between consumption of a Mediterranean diet and decreased risk of vascular events, supporting a diet rich in fruit, vegetables, whole grains, fish and olive oil as a way to promote health and decrease cardiovascular risks. 
American Journal of Nutrition 2011 Dec; 94(6):1458-64. (Gardener et al.)

Heart Function and the Mediterranean Diet

Seeking better understanding of how patients with chronic heart failure could slow progression of the disease, scientists in Greece studied the diet habits of 372 patients with this condition. They found positive associations between different factors of systolic and diastolic function in both heart ventricles and various element of the Mediterranean diet, including fish intake, olive oil use, pasta intake, and moderate alcohol drinking.

Heart Vessels, September 27, 2011 [Epub ahead of print]

Mediterranean Diet Reduces Risks from Atrial Fibrillation

In a case-controlled study at the University of Modena and Reggio Emilia in Italy, scientists compared 400 subjects with known atrial fibrillation to 400 matched controls with no evidence of this type of abnormal heart rhythm. They found that those with atrial fibrillation scored lower on the Mediterranean Diet score, and had fewer antioxidants in their diets. Researchers think that the hearts of the controls, with their healthier Med-style diets, were more likely to experience “spontaneous conversion” – a quick self-correction –of any arrhythmias that did occur
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Nutrition, Metabolism, and Cardiovascular Disease, July 26, 2011 [Epub ahead of print]

Countering the Effect of Depression in Elderly Heart Attack Patients

Many studies have found links between heart disease and depression. Researchers in Greece set out to study whether elderly patients (mean age 75 years) admitted to the hospital for acute heart disease were more likely to suffer another cardiovascular incident within 30 days if they exhibited symptoms of depression. The scientists did, in fact, find that depressive symptoms heightened the risk of this type of relapse, but that higher adherence to the Mediterranean Diet erased the association.

Cardiology Research and Practice, 2011: 429487 [Epub May 9, 2011]

High-Phenolic Olive Oil Protects Arteries Best

Oxidized LDL (low-density lipoprotein, or “bad cholesterol”) has been shown to increase the risk of atherosclerosis (hardening of the arteries). Oxidized LDL antibodies (OLAB) have been shown, in studies, to protect against atherosclerosis. Scientists in five European countries working as part of the EUROLIVE Study Group designed a crossover study to see whether higher polyphenol levels in different olive olis would generate more OLABs. 200 healthy men were randomly assigned to consume, in three week stints, 25mL a day (just under two tablespoons) of each of three olive oils with high, medium, and low phenolic content. The researchers found that the protective OLABs increased in direct relationship to the phenolic content of the olive oils.

Clinical Nutrition, March 3, 2011 [Epub ahead of print]

MUFAs are Protective Against Heart Disease and Metabolic Syndrome

Our understanding of the role of fats in our diet is shifting from a focus on the total quantity of fat to one emphasizing the quality of fats. Scientists at the University of Manitoba carried out a thorough review of research detailing the association of mono-unsaturated fatty acids (MUFAs) with cardiovascular disease and with metabolic syndrome. They concluded that MUFAs are cardioprotective and reduce the risk of obesity, particularly when they are substituted for saturated fats.

Lipids, February 10, 2011 [Epub ahead of print]

Brain MRIs show Less Disease with Med Diet

Scientists at the Taub Institute for Research in Alzheimer’s Disease and the Aging Brain (at U.C. Davis) collected high-resolution MRI (magnetic resonance imaging) data on the brains of 707 elderly New Yorkers. They then studied dietary assessments of these people from the past 5.8 years (on average), and divided the participants into three groups according to Mediterranean Diet adherence. They found that participants in the top-adherence group had 36% less evidence of cerebrovascular disease, and those in the middle group had 22% reduced odds, and concluded that “higher adherence to the Mediteranean Diet is associated with reduced cerbrovascular disease burden.”

Annals of Neurology, February 2011; 69(2): 257-68

Med Diet Improves Longevity Markers, Insulin Sensitivity

Scientists at the University of Naples studied 192 overweight and obese men, putting half the men on a Med Diet (if overweight) or a Med Diet plus exercise and calorie restriction (if obese), while the other half followed a conventional diet. After two years, the Med Diet group had lost, on average 14 kg (31 lbs), while the control group had lost just 2 kg. Moreover, the Med Diet group showed “significant amelioration of multiple risk factors” including improved cardiovascular markers, reduced oxidative stress, and improved insulin sensitivity. 

Cardiology Research & Practice, Dec. 20, 2010; 2011:293916

Higher Phenols Beneficial in Extra-Virgin Olive Oil

Oxidative DNA damage is one of the metabolic precursors to cancer and coronary vascular disease and phenols are organic compounds with antioxidant properties. A study conducted in Florence, Italy measured the oxidative DNA damage in ten healthy, post-menopausal women when they consumed olive oils with different concentrations of natural phenols. Subjects replaced fats and oils habitually consumed with the study oil (50g/d), which was either a high-phenol extra virgin olive oil (592 mg total phenols/kg) or a low-phenol extra virgin olive oil (147 mg total phenols/kg) for eight weeks in each period.  The study found that during treatment of high-phenol-EVOO, the average oxidative DNA damage was 30% lower than the average during low-phenol-EVOO treatment. Though the sample size was small, the study indicated that consuming an extra-virgin olive oil rich in phenols, particularly hydroxytryosol, may reduce DNA damage.
British Journal of Nutrition 2006 Apr; 95(4): 742-51 (Salvini et al.)
 

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