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Mediterranean Diet Reduces Risk of Heart Attack and Stroke

Randomized controlled trials, in which people are randomly assigned to a particular treatment and then monitored over time, are considered by many to be the “gold standard” of nutrition research. In this randomized controlled trial, 1,002 Spanish adults (average age 59) with heart disease were randomly assigned to a Mediterranean diet or a control diet (which differed by emphasizing lean meats and fish and low-fat dairy, and restricting fatty fish, nuts and olive oil) and followed for 7 years. Those eating a Mediterranean diet were 25-29% less likely to have a major cardiovascular event (such as a heart attack or stroke) than those eating the control diet, with the relationship being especially strong in men. These findings are consistent with previous research noting the cardioprotective benefits of a Mediterranean diet. 
Lancet. 2022 May 4;S0140-6736(22)00122-2. doi: 10.1016/S0140-6736(22)00122-2. (Delgado-Lista J et al.)

Mediterranean Diet Linked with Lower Risk of Preeclampsia

Preeclampsia is a pregnancy complication characterized by a rapid rise in blood pressure. In this study, researchers surveyed a diverse cohort of Black, Hispanic, and white low-income mothers in Boston about their diet and searched their health records for diagnoses of preeclampsia. Greater adherence to the Mediterranean diet was linked with a 22% lower risk of preeclampsia overall, with significant risk reduction for each of the racial groups.
Journal of the American Heart Association. 2022 May 3;11(9):e022589. doi: 10.1161/JAHA.121.022589. (Minhas AS et al.)

Mediterranean Diet Linked with Lower Risk of Alzheimer’s, Parkinson’s

Diet and lifestyle are thought to play a role in the risk for neurodegenerative diseases like Alzheimer’s and Parkinson’s, and researchers wonder if the gut microbiome may modulate this relationship. A review of 64 studies analyzed the relationship between the Mediterranean diet and risk of Alzheimer’s disease and/or Parkinson’s disease, as well as the relationship between the makeup of the gut microbiome and its association with both diet and neurodegenerative diseases. Greater adherence to a Mediterranean diet was linked with a lower risk of both Alzheimer’s and Parkinson’s disease. The study also identified specific genera and species of bacteria that had an inverse relationship with the Mediterranean diet and these diseases, suggesting that the gut microbiota may play a role in this relationship.
J Neurol Sci. 2022 Mar 15:434:120166. doi: 10.1016/j.jns.2022.120166. (Solch RJ et al.)

Mediterranean Diet Linked with Lower Risk of Alzheimer's and Parkinson's Diseases

The Mediterranean diet is thought to be neurologically protective, so researchers wanted to learn more about the diet’s relationship with neurodegenerative diseases like Alzheimer’s and Parkinson’s. In this study, researchers analyzed 64 articles about the Mediterranean diet, microbiome health, and Alzheimer’s disease or Parkinson’s disease. They found that following a Mediterranean diet is linked with a lower risk of Alzheimer’s Disease and Parkinson’s Disease (with the link for Alzheimer’s being particularly strong). However, it is unclear if the Mediterranean diet promotes gut microbiome health and brain health via two separate mechanisms or if one factor causes another.
Journal of the Neurological Sciences. 2022 Mar 15;434:120166. doi: 10.1016/j.jns.2022.120166. (Solch RJ et al.)

Mediterranean Diet Linked with Healthy Aging

Healthy eating may reduce the risk of age-related diseases and potentially even increase longevity, so researchers wanted to learn more about the mechanisms behind this protective effect. In this review, researchers share how the Mediterranean diet impacts nine different cellular and molecular hallmarks of aging (including telomere attrition, altered intercellular communication, and deregulated nutrient sensing, among others), thus supporting healthy aging.
European Journal of Clinical Nutrition. 2021 Aug;75(8):1176-1192. doi: 10.1038/s41430-020-00841-x. (Shannon OM et al.)

Mediterranean Diet Can Slow Progression of Atherosclerosis

Atherosclerosis, the build up of fatty plaque in arteries, can be a risk factor for heart disease down the road. In a randomized controlled trial of more than 900 people with heart disease, those assigned to a Mediterranean diet improved their atherosclerosis (as measured by reduced thickness of both carotid arteries) over 5 years and maintained their baseline artery thickness at 7 years. Those assigned to a low-fat diet did not have any significant improvements in atherosclerosis.
Stroke. 2021 Aug 10;STROKEAHA120033214. doi: 10.1161/STROKEAHA.120.033214. (Jimenez-Torres J et al.)

Following a Mediterranean Diet May Have “Halo Effect” on Other Family Members

Can healthy eating habits rub off on family members who aren’t actively trying to eat better? New research seems to suggest so. In this study, scientists analyzed the diet, weight, and exercise habits of 148 untreated family members of people participating in the PREDIMED-Plus study, a Mediterranean diet weight loss intervention. After two years, the untreated family members lost nearly 9 pounds and scored significantly better on the Mediterranean diet score, indicating a “halo effect” of their family members’ participation in the study. There were no significant changes to the exercise habits of the untreated family members.
International Journal of Obesity. 2021 Jun;45(6):1240-1248. doi: 10.1038/s41366-021-00763-z. Epub 2021 Mar 3. (Zomeño MD et al.)

Mediterranean Inspired MIND Diet Linked with Healthier Brain Markers in MS

The Mediterranean diet is well-known for its brain benefits, so scientists wonder how Mediterranean-inspired eating might relate to multiple sclerosis (MS), a brain and spinal cord autoimmune disease. Researchers analyzed the eating habits and brain structures of 180 adults who have had a diagnosis of MS for less than 5 years to see how closely they adhered to a version of the Mediterranean diet called the MIND diet. The MIND diet is a hybrid Mediterranean-DASH diet that emphasizes foods associated with brain health, including whole grains, green leafy vegetables, berries, nuts, olive oil, and fish. In this study, people most closely following the MIND diet had significantly greater thalamic volumes. (The wasting away of the thalamus is a marker of MS disease progression and neurodegeneration, so greater thalamic volume is a good sign that MS might be advancing slower.) Additionally, when looking at specific foods and nutrients, those eating the most full-fat dairy had fewer brain lesions (as measured by lower volumes of T2 lesions) and those eating the most omega-3’s from fish had better microstructural integrity of their normal appearing white matter.
Multiple Sclerosis and Related Disorders. 2021 May 19;53:103031. doi: 10.1016/j.msard.2021.103031. (Katz Sand IB et al.)

Mediterranean Diet Linked with Lower Risk of Memory Decline in Elderly

The Mediterranean diet has long been studied for its link with brain health, and now researchers are starting to understand the mechanisms behind this protective relationship. In a study of 512 older adults (average age 69) who were a mixture of people both with and without a family history of Alzheimer’s, researchers found that more closely following a Mediterranean diet was linked with significantly better memory, larger gray matter volume in the area of the brain related to memory (mediotemporal), and less pTau181 (a predictor of Alzheimer’s progression) and amyloid pathology (misfolded proteins in the brain which are associated with Alzheimer’s progression).
Neurology. 2021 May 5;10.1212/WNL.0000000000012067. doi: 10.1212/WNL.0000000000012067.(Ballarini T et al.)

Maternal Mediterranean Diet May Relate to Children’s Weight Later in Life

Childhood obesity is a rising public health concern and a strong predictor of obesity later in life. Previous studies have discovered that mothers’ diets during pregnancy can potentially impact children’s weight and their risks of developing obesity. This study evaluated how mothers’ dietary patterns during pregnancy affect their children’s BMI (body mass index). A total of 1,459 women participated in the study and completed a questionnaire about the food they ate during pregnancy. Their children were followed up for 15 years to measure their weight and height change. The findings showed that children whose mothers had closely followed the Mediterranean diet during pregnancy are more likely to grow faster and have lower BMI than their peers during childhood. However, the researchers cautioned that differences in breastfeeding might partly explain the BMI differences across the groups. Thus, more studies are needed.
American Journal of Clinical Nutrition. 2021 Mar 15;nqaa398. doi: 10.1093/ajcn/nqaa398. (Monthé-Drèze C et al.)

Mediterranean Diet Linked with Slower Prostate Cancer Progression, Better Survival

Many patients diagnosed with prostate cancer don’t need immediate intervention, so strictly monitoring the disease progression is critical. This study collected data from 410 men diagnosed with prostate cancer and measured how closely they were following the Mediterranean Diet. After 36 months of follow-up, those most closely following a Mediterranean diet were less likely to have significant disease progression, and were more likely to have a better rate of survival.
Cancer. 2021 Mar 1; 127(5):720-728. doi:10.1002/cncr.33182. (Gregg JR et al.)

Mediterranean Diet Linked with 20% Lower Risk of Dementia

Dementia is an age-related disease causing memory loss and confusion, and over 50 million people suffer from dementia globally. Because there is currently no effective treatment for it, prevention is pivotal. To investigate whether the Mediterranean Diet has a protective effect on dementia, the researchers studied 16,160 middle-aged adults and followed them for over 20 years. Among all the participants, 459 were diagnosed with dementia. When comparing the dietary patterns between those with and without dementia, the researchers found that those most closely following the  Mediterranean diet,  were 20% less likely to develop dementia. However, the results were not statistically significant when looking at Alzheimer’s dementia.
Nutrients. 2021 Feb 22;13(2):700. doi: 10.3390/nu13020700. (Andreu-Reinon ME et al.)

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