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Mediterranean Diet Reduces Risk of Heart Attack and Stroke

Randomized controlled trials, in which people are randomly assigned to a particular treatment and then monitored over time, are considered by many to be the “gold standard” of nutrition research. In this randomized controlled trial, 1,002 Spanish adults (average age 59) with heart disease were randomly assigned to a Mediterranean diet or a control diet (which differed by emphasizing lean meats and fish and low-fat dairy, and restricting fatty fish, nuts and olive oil) and followed for 7 years. Those eating a Mediterranean diet were 25-29% less likely to have a major cardiovascular event (such as a heart attack or stroke) than those eating the control diet, with the relationship being especially strong in men. These findings are consistent with previous research noting the cardioprotective benefits of a Mediterranean diet. 
Lancet. 2022 May 4;S0140-6736(22)00122-2. doi: 10.1016/S0140-6736(22)00122-2. (Delgado-Lista J et al.)

Frequent Olive Oil Consumption May Be Linked with Making Blood Less Likely to Clot

Olive oil is a well-known heart healthy food, and new research sheds light on a potential explanation behind this benefit. In this study, researchers analyzed the eating habits of 63 obese but otherwise healthy adults, and also analyzed the platelet activity in their blood. (Platelets are the building blocks of blood clots when they stick together.) Those eating olive oil at least once per week had significantly lower platelet activation, indicating that their blood may be less likely to clot. (Note that findings presented at meetings are considered preliminary until published in a peer-reviewed journal.)
Presentation at American Heart Association’s Epidemiology and Prevention | Lifestyle and Cardiometabolic Health Scientific Sessions. Houston, TX. March 7, 2019 (Heffron SP et al.)

Mediterranean Diet Linked with 22% Lower Risk of Stroke in Women

The Mediterranean diet has been well studied for its link to stroke prevention, but researchers wonder how the effects may differ between different types of patients. In this study, scientists monitored the eating patterns and health status of 23,232 white Europeans in the UK. After 17 years, those most closely following a Mediterranean diet had a 17% lower risk of stroke. However, the findings seem to be driven primarily by women. Women who most closely followed a Mediterranean diet had a 22% lower risk of stroke, while the trend towards lower risk in men was not statistically significant. Additionally, the findings were stronger in people who had a higher risk of heart disease (due to family history or other factors).
Stroke. 2018 Sept 20. doi: 10.1161/STROKEAHA.117.020258. [Epub ahead of print.] (Paterson KE et al.)

Mediterranean-Inspired Diet May Slow Cognitive Decline in Stroke Survivors

Stroke survivors are twice as likely to develop dementia compared to the general population. To see how diet relates to brain health in stroke survivors, researchers analyzed the eating patterns and brain function of 106 stroke survivors for more than 4 years. Those most closely following a “MIND diet” had a slower rate of cognitive decline than those who don’t follow a MIND diet. The MIND diet is a hybrid Mediterranean-DASH diet that emphasizes foods associated with brain health, including whole grains, green leafy vegetables, berries, nuts, olive oil, and fish. The Mediterranean diet is well-known for its brain benefits, so it’s not surprising that this new diet inspired by the Mediterranean diet is also showing promise for brain health. 
Presentation at the American Heart Association Meeting. Los Angeles, California. January 25, 2018. 

Eating Fish Linked with 40% Lower Risk of Heart Disease

Fish is well recognized for its role in a heart-healthy diet. To learn more about how fish eating relates to heart disease risk in a Mediterranean population, scientists analyzed the eating patterns and health outcomes of nearly 21,000 Italian adults. Those eating fish at least 4 times per week were 40% less likely to develop coronary heart disease than those eating fish fewer than 2 times per week. This relationship is primarily driven by fatty fish, like salmon, trout, herring, mackerel, and canned fish. Strokes were also studied, but the trend toward lower stroke risk in frequent fish eaters was not statistically significant.
Nutrition, Metabolism, and Cardiovascular Diseases. 2017 Aug 23. pii: S0939-4753(17)30198-9. (Bonaccio M et al.)

Mediterranean Diet Linked with Lower Risk of Heart Disease & Death from Heart Disease

Even if you don’t live in the Mediterranean, you can still benefit from a Mediterranean style diet. To see how the Mediterranean diet relates to heart disease in England, European researchers analyzed the eating habits and health outcomes of 23,902 adults (age 40-79) in Eastern England. Those most closely following a Mediterranean diet were significantly less likely to develop heart disease. Based on these data, the researchers estimate that 1-6% of all heart disease cases, and 2-14% of all stroke cases can be prevented by following a Mediterranean diet.
BMC Medicine. 2016 Sep 29;14(1):135. (Tong TY et al.)

Mediterranean Diet and Genetic Risk of Stroke

Researchers from the Jean Mayer USDA Human Nutrition Research Center on Aging (USDA HNRCA) at Tufts University and from the CIBER Fisiopatalogía de la Obesidad y Nutritión in Spain have found that the Mediterranean Diet reduces stroke risk in people with a gene variant associated with the development of type 2 diabetes. Working with the data from the PREDIMED study, researchers identified that patients carrying two copies of the Transcription Factor 7-Like 2 (TCF7L2) gene, which is known to place patients at high risk for type 2 diabetes and suspected of connections with other diseases, had a risk factor for stroke almost three times higher than those with only one copy or no copies of the gene. But patients with two copies of the gene who adhered to a Mediterranean Diet reduced their risk for stroke to the same levels as those with one or no copies of the gene.

Diabetes Care. Epub 2013 August 13. [Corella, et al.].

Med Diet Helps Prevent Cardiovascular Disease

A landmark clinical trial of nearly 7,500 people reveals that the Mediterranean Diet may reduce the risk of cardiovascular disease by up to 30 percent and may also reduce the risk for stroke among high-risk patients. Study participants were randomly assigned to one of three groups: Med Diet with at least 4 tablespoons of olive oil daily; Med Diet with an ounce of nuts daily; and a control group receiving advice on a low-fat diet. The two Med groups had no trouble following their instructions to enjoy five servings of fruits and vegetables, fish and legumes each three or more times a week, white meat instead of red, and wine (for those who drink), while avoiding commercial cookies and cakes, dairy products, and processed meats. The low-fat group morphed into a “typical Western diet” group. The study’s results were so clear that researchers halted the study earlier than planned because it was deemed unethical to prevent the control group from switching to a Mediterranean Diet.
The New England Journal of Medicine. 2013 February 25. [Estruch, et al.]

 

Med Diet Lowers Risk of Overall Heart Disease

Researchers at the University of Miami examined the relationship between a Mediterranean diet and risk of ischemic stroke, myocardial infarction, and vascular death among 2568 participants (black, Hispanic and white). Adherence to the Mediterranean diet was assessed using a food frequency questionnaire; the higher the score the greater the adherence to the Mediterranean diet.  The relationship between the Mediterranean diet and risk of ischemic stroke, myocardial infarction, and vascular death was assessed using Cox models, with control for socio-demographic and vascular risk factors.  Over a mean follow-up of 9 years, 518 vascular events accrued (171 ischemic strokes, 133 MI’s, and 314 vascular deaths).  The results of this study showed an inverse relationship between consumption of a Mediterranean diet and decreased risk of vascular events, supporting a diet rich in fruit, vegetables, whole grains, fish and olive oil as a way to promote health and decrease cardiovascular risks. 
American Journal of Nutrition 2011 Dec; 94(6):1458-64. (Gardener et al.)

Olive Oil May Be Protective Against Strokes

Older people who consume plenty of olive oil may reduce their risk of stroke by as much as 41%. That’s the conclusion of researchers from the University of Bordeaux, who followed more than 7,000 people over the age of 65, in the French cities of Bordeaux, Dijon, and Montpelier, for more than five years. Compared to those who seldom or never used olive oil, those with the heaviest self-reported use of olive oil lowered their risk of suffering a stroke during the five-year duration of the study from 2.6% to 1.5% – a 41% drop.

Neurology, June 15, 2011 [Epub ahead of print]